After a brutal homestand capped off by losing five players to the IL for health and safety protocols, the once 5-1 Astros brought their now 6-6 record to T-Mobile park in Seattle to try and right the ship. They'd have to do it with new and young players in the lineup using the "next man up" mentality to get some wins against the first-place Mariners.

Though the young bats would work themselves into a lead most of the night, Houston's bullpen wouldn't be able to hold the Mariners down, with Seattle ultimately walking things off in the ninth.

Final Score: Mariners 6, Astros 5

Astros' Record: 6-7, fourth in the AL West

Winning Pitcher: Anthony Misiewicz (2-0)

Losing Pitcher: Ryne Stanek (0-1)

After a quiet start, Houston gets three in the fifth

After cruising through the Astros through the first four innings, allowing only a walk over that span, Houston was able to put up a big inning against Yusei Kikuchi in the top of the fifth. Carlos Correa notched the first hit of the night, followed by a walk by Taylor Jones to put two on base.

That brought Alex De Goti, making his major-league debut, to the plate and, in his second career at-bat, would get his first hit and RBI, bringing in Correa from second on a single. A second run would come on the same play on a throwing error, then Chaz McCormick made it a three-run inning with an RBI-double, putting Houston out front 3-0.

Urquidy comes an out shy of a quality start

Meanwhile, Jose Urquidy was doing well through five innings. On track for a much-needed quality start, the Mariners would tag him in the bottom of the sixth, getting three-straight hits to bring in two runs to lead off the frame and leaving a runner on second base with no outs.

Urquidy would rebound to get the next two batters on strikeouts, but at 90 pitches and with a left-handed hitter up next, Dusty Baker would bring in lefty Brooks Raley to try and get out of the inning with the one-run lead intact. Raley would do his job, putting Uruidy's line final: 5.2 IP, 5 H, 2 ER, 2 BB, 7 K, 90 P.

Teams trade two-run seventh innings

Taylor remained in the game in the bottom of the eighth, and after getting an out, would allow a game-tying solo home run to Evan White before injuring himself trying to field an infield single. Ryne Stanek entered and finished off the eighth, sending the tie game to the ninth.

After Houston came up empty in the top half, Stanek remained in the game in the bottom of the ninth, attempting to force extras. Back-to-back walks ended Stanek's night, with the Astros hoping Ryan Pressly could bail them out. He couldn't, though, giving up the walk-off hit as the Mariners would take the opener, 6-5.

Up Next: Game two of this three-game set will start an hour earlier on Saturday, with first pitch at 8:10 PM Central. Zack Greinke (1-1, 4.08 ERA) will try to rebound from a poor start his last time out for the Astros, while the Mariners will hand the ball to Chris Flexen (1-0, 4.50 ERA).