The Houston Astros (32-27) travel to Pittsburgh to open a three-game series against the Pirates (22-38) on Tuesday night at PNC Park. First pitch is scheduled for 6:40 p.m. EDT, with Houston sending Lance McCullers Jr. to the mound opposite electric rookie Paul Skenes.

McCullers (0-1, 5.89 ERA) is still searching for rhythm in just his sixth start since returning to the rotation. The veteran right-hander will need sharper command against a Pirates lineup that’s shown signs of life over the past week. Pittsburgh counters with Skenes (4-5, 2.15 ERA), whose early MLB run has been dominant. With a 0.92 WHIP and 77 strikeouts in just nine starts, the top prospect has already made himself a must-watch arm.

Houston enters the series riding a 7-3 run over its last 10 games, powered by a .288 team batting average in that span. Despite being outscored by one run during that stretch, the Astros' offense has shown signs of clicking. Jose Altuve is on a tear, batting .385 with five home runs and eight RBIs over the last 10 games, while Jeremy Peña continues to lead the team with a .309 average and nine long balls on the season.

The Pirates have gone 5-5 in their last 10 and have been more competitive than their record suggests. They’ve outscored opponents by seven runs during that stretch while hitting .272 and posting a 3.89 ERA. Oneil Cruz remains the top power threat with 12 home runs, and Andrew McCutchen has turned in a strong week at the plate, going 13-for-37 with a pair of homers.

This is the first meeting between the two clubs this season. The Pirates are slight home favorites at -146 on the moneyline per BetMGM, with the over/under set at 7.5 runs. Houston, just 10-15 on the road, will be looking to set the tone early as they continue to chase down first-place Seattle in the AL West.

Injury update

The Astros informed The Athletic's Chandler Rome that Zach Dezenzo is dealing with a "capsule sprain" in his left hand, and they will undergo imaging on the hand again after two weeks of rest.

Here's a sneak peek at the Astros' lineup versus Skenes. Jacob Melton gets another start, this time playing left field. Altuve is getting the nod at second base with Yainer Diaz in the DH spot.

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