Rookie Ceddanne Rafaela doubled twice with two RBIs and fellow rookie David Hamilton added a solo homer in the ninth inning to lead the Boston Red Sox to a 4-1 win over the Houston Astros on Wednesday.

Rafaela’s first double off Justin Verlander (3-3) gave Boston a 2-1 lead in the second inning. He drove in another run with a double with two outs in the seventh.

Hamilton’s home run to right field off Seth Martinez made it 4-1 with two outs in the ninth.

The Red Sox, who were swept by the AL West-leading Astros at home earlier this month, won this series after getting a 6-5 victory Tuesday night.

Alex Bregman hit his first career leadoff home run in his return to the lineup after missing five games with a swollen right elbow. But the Astros struggled at the plate the rest of the day, going 0 for 7 with runners in scoring position after finishing 0 for 8 Tuesday.

Bregman was batting first for just the third time this season with Jose Altuve getting a rare day off.

Verlander allowed four hits and two runs with six strikeouts in five innings in his first start since June 9. The 41-year-old, who was out with stiffness in his neck, threw 76 pitches after tossing 57 in his second rehabilitation start Thursday.

Red Sox starter Cooper Criswell permitted four hits and a run in 4 2/3 innings. Josh Winckowski (4-1) pitched a scoreless sixth for the win and Chris Martin struck out one in the ninth for his first save.

The Astros had a chance to take the lead in the seventh. Jake Meyers and Mauricio Dubón hit back-to-back singles with no outs in the bottom of the seventh and they both moved up a base on a wild pitch by Greg Weissert.

Pinch-hitter Jon Singleton struck out before pinch-hitter Trey Cabbage walked to load the bases. Bregman was retired on a foul ball Wilyer Abreu caught in foul territory before Weissert was replaced by Brennan Bernardino.

He struck out Yordan Alvarez on an outside pitch to end the threat and cause a frustrated Alvarez to toss his bat.

Jarren Duran, who went 4 for 4 Tuesday night, led off with a double before scoring on a one-out single by Triston Casas to put the Red Sox up early.

Connor Wong was on first with two outs in the second when Rafaela doubled off the wall in left field to put Boston back on top 2-1.

Masataka Yoshida singled to start the seventh and stole second base with one out. There were two outs in the inning when Rafaela doubled on a line drive to the corner of left field to score Yoshida and make it 3-1.

TRAINER’S ROOM

Astros: Martinez was sent to Triple-A Sugar Land after Tuesday night’s game to make room for Verlander on the roster. But he was recalled before Wednesday’s game after RHP Kaleb Ort was placed on the paternity list.

UP NEXT

Red Sox: Boston is off Thursday and hasn’t released its rotation for a three-game series against the Diamondbacks that starts Friday night.

Astros: Houston hasn’t announced its rotation for a four-game series that starts Thursday night in Baltimore.